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02/09/10(Tue)06:48:14 No.7435624Photocarcinogenesis
and toxicity of benzoyl peroxide in hairless mice after simulated solar
radiation Catharina M. Lerche 1 , Peter A. Philipsen 1 , Thomas
Poulsen 2 and Hans Christian Wulf 1 1 Department of Dermatology,
Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark ; ABSTRACT
Abstract:
Topical benzoyl peroxide (BPO) gel has long been used to treat acne
vulgaris and has recently been combined with clindamycin (BPO-clin). No
skin malignancies have been reported after clinical use of BPO, but
there has been concern about the possible carcinogenicity of BPO alone
and in combination with UV radiation. BPO can promote skin tumorigenesis
in a mouse skin chemical carcinogenesis model. As acne vulgaris is
frequently localized on sun-exposed areas, we investigated whether BPO
or BPO-clin accelerates photocarcinogenesis in combination with
simulated solar radiation (SSR) in 12 groups of 25 hairless female
C3.Cg/TifBomT-immunocompetent mice. BPO or BPO-clin was applied
topically to the back five times each week, followed by SSR three times
each week (2, 3, or 4 standard erythema doses) 3-4 h later, for 365 days
or until death. Generally BPO and BPO-clin did not accelerate the time
to first, second or third tumor. Therefore, there is no evidence
suggesting that BPO or BPO-clin is photocarcinogenic. However, we found
significantly higher mortality in the SSR exposed groups receiving BPO
and BPO-clin compared with groups receiving only BPO or BPO-clin. Our
results show that BPO and the combination of BPO and clindamycin do not
accelerate photocarcinogenesis, but are toxic in hairless mice. Based on
the current data, the cancer risk associated with the use of BPO and
BPO-clin in sun-exposed areas is minimal. Thus, while the carcinogenic
potential of BPO is not fully understood, at the present time, evidence
suggests that this compound is safe to use. |