1 October 2003 Source: http://www.access.gpo.gov/su_docs/aces/fr-cont.html ----------------------------------------------------------------------- [Federal Register: September 30, 2003 (Volume 68, Number 189)] [Notices] [Page 56296-56298] From the Federal Register Online via GPO Access [wais.access.gpo.gov] [DOCID:fr30se03-80] ----------------------------------------------------------------------- DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Candidate Chemicals for Possible Inclusion in Future Releases of the National Report on Human Exposure to Environmental Chemicals AGENCY: Centers for Disease Control and Prevention (CDC), Health and Human Services (HHS). ACTION: On Monday, October 7, 2002, CDC published final selection criteria and solicited nominations for chemicals or categories of chemicals for analytical development and inclusion in future releases of the National Report on Human Exposure to Environmental Chemicals (the ``Report''). (See 67 FR, p. 62477-8, October 7, 2002.) Subsequently, the nominated chemicals were published on CDC's Web site, http://www.cdc.gov/exposurereport. CDC now provides the list of candidate chemicals by priority groups that may be included in future releases of the ``Report.'' Using the selection criteria and the weighting factors described in the above-mentioned notice, an expert panel of outside reviewers and scientists at CDC's National Center for Environmental Health, Division of Laboratory Sciences, scored nominated individual chemicals or categories of chemicals. On the basis of their final point score, chemicals were placed in one of five priority groups. Listing these chemicals or categories of chemicals in priority groups does not imply that CDC has determined that exposure to them causes adverse human health effects. The nominations enabled CDC to learn which chemicals or categories concerned the public and the scientific community. Chemicals in the priority groups are listed in alphabetical order. Chemicals in Group 1 are more likely, but not guaranteed, to appear in future releases of the ``Report'' than are chemicals in the remaining groups. In addition to appearing in the Federal Register, the list of candidate chemicals will appear on CDC's Web site at http://www.cdc.gov/exposurereport/candidatechemicals. CDC will publish additional notices in the Federal Register as needed to keep the public abreast of progress. ----------------------------------------------------------------------- Candidate Chemicals in Priority Groups Group 1 [in alphabetical order] 1,3-Butadiene 1-Decanesulfonic acid, 1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10, 10, 10- heneicosafluoro, ammonium salt Aldicarb Benzo[a]pyrene Dichlorvos (DDVP) Diesel exhaust Dimethoate Ethylene dibromide Fonofos Formaldehyde Isodrin Mancozeb Manganese Methyl bromide N-methyl perfluorooctanesulfonamidoacetate (M570) Octabromodiphenyl ether (OBDE) Oxamyl Pentabromodiphenyl ether (PeBDE)--congeners include BDE 82, 116, and 119 Perfluorinated carboxylic acid metabolites of telomer alcohol or telomer acrylate (n = 3) Perfluorobutane sulfonate (PFBS) [[Page 56297]] Perfluorooctanoic acid fluoride Perfluorooctanoic acid (PFOA) ammonium salt* PFOA ethyl ester PFOA free acid PFOA methyl ester PFOA potassium salt* PFOA silver salt* PFOA sodium salt* Perfluorooctane sulfonate (PFOS) ammonium salt* PFOS diethanolamine salt* PFOS lithium salt* PFOS potassium salt* Phorate Phosmet trans Fatty acids *PFOA and PFOS measured as a consequence of exposure to any PFOA or PFOS salt. Group 2 [in alphabetical order] 2,2',4,4'-Tetrachlorobiphenyl (PCB 47) 2,3,4,4',5-Pentachlorobiphenyl (PCB 114) 2',3,4,4',6- Pentachlorobiphenyl (PCB 123) Acetaldehyde Acrolein Amitrole Anthracene Benzo[j,k]-fluorene Bifenthrin Butylate (Carboxymethylamino) methylphosphonic acid (Glyphosate) Chromium (speciated and total) Diaminochlorotriazine Lambda cyhalothrin Methomyl Mevinphos Molinate N-methyl-N-ethylnitrosamine N-nitrosodibutylamine N-nitrosodiethanolamine N-nitrosodiethylamine N-nitroso-dimethylamine (NDMA) N-nitrosodiphenylamine N-nitrosodipropylamine Pebulate Pendimethalin Pentachloronitrobenzene Perchlorate Perfluorodecanesulfonate (PFDS) ammonium salt Perfluorooctanesulfonamidoacetate (M556) Propazine Selenium (speciated and total) Simizine Thiram Tin (speciated and total) Triclosan Trifluralin Group 3 [in alphabetical order] 4,4'-Dichlorobiphenyl (PCB 15) 2,2',3,3',4,4',5,6,6'-Nonachlorobiphenyl (PCB 207) 2,2',3,3',4,4',6-Heptachlorobiphenyl (PCB 171) 2,2',3,3',4,4',6,6'-Octachlorobiphenyl (PCB 197) 2,2',3,3',5,5'-Hexachlorobiphenyl (PCB 133) 2,2',3,4,4,'5-Hexachlorobiphenyl (PCB 137) 2,2',3,4,4',5,6'-Heptachlorobiphenyl (PCB 182) 2,2',3,4,4',5,6-Heptachlorobiphenyl (PCB 191) 2,2',3,4,4',5,6,6'-Octachlorobiphenyl (PCB 204) 2,2',3,4,4',6,6'-Heptachlorobiphenyl (PCB 184) 2,2',3,4,4',6-Hexachlorobiphenyl (PCB 139) 2,2',3,4,4',6'-Hexachlorobiphenyl (PCB 140) 2,2',3,4,4'-Pentachlorobiphenyl (PCB 85) 2,2',4,4',5,6'-Hexachlorobiphenyl (PCB 154) 2,2',4',4',6-Pentachlorobiphenyl (PCB 100) 2,3,3',4,4',5,5',6-Octachlorobiphenyl (PCB 205) 2,3,3',4,4',5,6-Heptachlorobiphenyl (PCB 190) 2,3,3',4',5,6'-Hexachlorobiphenyl (PCB 163) 2,3,3',5,5',6-Hexachlorobiphenyl (PCB 165) 2,3,4,4',5,6-Hexachlorobiphenyl (PCB 166) 2,3,4,4',5',6-Hexachlorobiphenyl (PCB 168) 2,3,4,4',6-Pentachlorobiphenyl (PCB 119) 2,4,4',6-Tetrachlorobiphenyl (PCB 75) 3,3',5,5'-Tetrachlorobiphenyl (PCB 80) 3,4,4'-Trichlorobiphenyl (PCB 37) Acephthene Aluminum Desethyl atrazine Desisopropyl atrazine Fenbuconazole Methiocarb Pentylphenol PFOS-related compounds (n = 11; a heterogeneous group) Radon Group 4 [in alphabetical order] Acenaphthylene Benzo[g,h,i]pyrene Butachlor Desethyl S-atrazine Desisopropyl S-atrazine Fluoroalkyl ethers (n = 6) Fluoroalkyl iodides (n = 3) Formetanate Gamma, omega-perfluoroalkyl alcohols (n = 3) 3-chloro-4(dichloromethyl)5-hydroxy-2(5H)furanone (MX) Other phased-out PFCs related to PFOS chemistries (n = 13) Perfluorinated carboxylic acid metabolites of telomer alcohol or telomer acrylate (n = 3) Perfluorinated chemicals not assigned to a structural class (n = 2) Perfluorinated homologues of PFOS and PFOA (n = 2) Perfluorinated quaternary ammonium chemicals (n = 2) Perfluoroalkanes (n = 3) Perfluoroalkyl acids and salts (n = 6) Perfluoroalkyl alcohols (n = 4) Perfluoroalkyl carboxylic acid fluorides (n = 2) Perfluoroalkyl esters (n = 5) Perfluoroalkyl iodides (n = 6) Perfluoroalkyl sulfonamides (n = 10) Perfluoroalkyl sulfonates (n = 75) Perfluoroalkyl sulfonyl fluorides (n = 4) Perfluoroglycol acid fluorides (n = 5) Primicarb Propiconazole Propylparaben Strontium Tebuconazole Thiodicarb Triadimefon Ziram Group 5 [in Alphabetical Order] 1,2,4-Trizole Acetamiprid Acetochlor ethane sulfonic acid Acetochlor oxanilic acid Alachlor ethane sulfonic acid Alachlor oxanilic acid Butylparaben Cerium Copper Dimethenamid Dimethenamid ethane sulfonic acid Dimethenamid oxanilic acid Ethylparaben Hexachlorocyclopentadiene (HCCPD) Iron Lanthanum lmidacloprid lmidazolinone herbicides (e.g., imazapyr, imazethapyr, imazaquin) Methylparaben Metolachlor ethane sulfonic acid Metolachlor oxanilic acid Myclobutanil Nickel Perfluorinated compounds that the U.S. Food and Drug Administration has approved as indirect food additives (n = 16) Perfluoroalkyl acids and salts (n = 2) Scandium Silver Sulfonyl urea herbicides (e.g., nicosulfuron, chlorsulfuron, triasulfuron) Tellurium Thiamethoxam Triazole actic acid Triazole aniline Vanadium Some chemicals that were nominated appeared in the second ``Report,'' which was published in January 2003. In addition, other chemicals or groups of chemicals that were already scheduled for inclusion in either the third or fourth release of the ``Report'' were not reviewed by the external expert panel and thus do not appear on the priority list. Chemicals or chemical categories that were included in the second ``Report,'' as well as those already slated for inclusion in future ``Reports,'' are listed below. Nominated Chemicals or Chemical Categories Already Measured in the Second ``Report'' Metals Cadmium Lead Mercury (inorganic and total) Tobacco Smoke Cotinine Polyaromatic Hydrocarbons (PAHs) Naphthalene (as the metabolites 1- and 2-naphthol) Organochlorine Pesticides Chlordane (as the metabolite oxychlordane) 4,4'-DDE (p,p'-DDE) 4,4'-DDT (p,p'-DDT) Heptachlor (as the metabolite heptachlor epoxide) Heptachlor epoxide Hexachlorobenzene Lindane (gamma HCH) Mirex [[Page 56298]] 1,2,4-Trichlorobenzene (as the metabolite 2,4,5-trichlorophenol) Organophosphate Pesticides Chlorpyrifos (as the metabolite 3,5,6-trichloro-2-pyridinol) Phenols ortho-Phenylphenol N-Methyl Carbamates Carbaryl (as the metabolite 1-naphthol) Carbofuran (as the metabolite carbofuranphenol) Propoxur (as the metabolite 2-isopropoxyphenol) Alachlor (as the metabolite alachlor mercapturate) Triazines Atrazine (as the metabolite atrazine mercapturate) Other Herbicides 2,4-Dichlorophenoxyacetic acid (2,4-D) Polychlorinated Biphenyls (PCBs) PCB numbers 52, 66, 81, 99, 101, 105, 118, 126, 128, 138, 146, 153, 156, 157, 167, 169, 170, 180, and 183 Nominated Chemicals or Chemical Categories Already Planned for Inclusion in Future ``Reports'' Metals Arsenic (speciated and total) Methyl mercury Volatile Organic Compounds (VOCs) Benzene 1,1,1-Trichloroethane 1,2-Dichlorobenzene Carbon tetrachloride Chloroform Ethylene dichloride Perchloroethylene Toluene Xylenes (o, m, p-isomers) Polybrominated Compounds Polybrominated biphenyls (PBBs) Polybrominated diphenyl ethers (PBDEs) Tetrabromodiphenyl ether (TeBDE) Pentabromodiphenyl ether (PeBDE) Heptabromodiphenyl ether (HpBDE) Decabromodiphenyl ether (DeBDE) Hexabromocyclododecane (HBCD) Tetrabromobisphenol A (TBBP-A) Organochlorine Pesticides alpha Hexachlorocyclohexane (HCH) Aldrin (as the metabolite endrin) 4,4'-DDD (p,p'-DDD; DDD) Dieldrin Endosulfan Endrin Methoxychlor Octachlorostyrene Pentachlorobenzene (as the metabolite pentachlorophenol) Toxaphene Chloroacetanilides Acetochlor (as the metabolite acetochlor mercapturate) Metolachlor (as the metabolite metolachlor mercapturate) Phenols Bisphenol A Nonylphenol Octylphenol Dithiocarbamates Ethylenethiourea Pyrethrins and Pyrethroids Cyfluthrin Cypermethrin Deltamethrin Esfenvalerate Fenvalerate Permethrin Perfluorinated Compounds Perfluorohexanoic sulfonic acid (PFHS) Perfluorooctane sulfonate (PFOS), including nominated salt forms Perfluorooctanoic acid (PFOA), including nominated salt forms Organophosphate Pesticides Acephate Azinophos-methyl (also as dialkyl phosphate metabolites) Coumaphos (also as dialkyl phosphate metabolites) Methamidophos Polychlorinated Biphenyls (PCBs) PCB numbers 77, 87, 151, 158, 189, 194, 195, 169, 203, 206, and 209 ADDRESSES: Address all correspondence related to this notice to Dorothy Sussman, CDC, National Center for Environmental Health, Division of Laboratory Sciences, Mail Stop F-20, 4770 Buford Highway, Atlanta, Georgia 30341. SUPPLEMENTARY INFORMATION: CDC publishes the ``Report'' under the authorities 42 U.S.C. 241 and 42 U.S.C. 242k. The ``Report'' provides an ongoing assessment using biomonitoring of the exposure of the noninstitutionalized, U.S. civilian population to environmental chemicals. Biomonitoring assesses human exposure to chemicals by measuring the chemicals or their breakdown products in human specimens such as blood or urine. For the ``Report,'' an environmental chemical means a chemical compound or chemical element present in air, water, soil, dust, food, or other environmental medium. The ``Report'' provides exposure information about participants in an ongoing national survey known as the National Health and Nutrition Examination Survey (NHANES). This survey is conducted by CDC's National Center for Health Statistics; biomonitoring measurements are conducted by CDC's National Center for Environmental Health. The first ``Report,'' published in March 2001, gave information about levels of 27 chemicals in the U.S. population. The second ``Report,'' published in January 2003, provided data on 116 chemicals, including expanded data on the 27 in the first ``Report,'' and was the most extensive assessment ever of the exposure of the U.S. population to environmental chemicals. The ``Report'' can be obtained in the following ways: Access http://www.cdc.gov/exposurereport; e-mail ncehdls@cdc.gov; or telephone 1-866-670-6052. Current plans are to release future reports of exposure of the U.S. population that cover 2-year periods (e.g., 2001-2002; 2003-2004; 2005- 2006) and that will include data on more chemicals than the 116 listed in the second ``Report.'' Over time, CDC will be able to track trends in exposure levels. Future releases also may include additional exposure information for special exposure populations (e.g., children, women of childbearing age, elderly people) from studies examining localized or point sources and from studies of adverse health effects resulting from exposure to varying levels of environmental chemicals. The Director, Management Analysis and Services Office, has been delegated the authority to sign Federal Register notices pertaining to announcements of meetings and other committee management activities for both the CDC and ATSDR. Dated: September 24, 2003. Alvin Hall, Director, Management Analysis and Services Office, Centers for Disease Control and Prevention. [FR Doc. 03-24671 Filed 9-29-03; 8:45 am] BILLING CODE 4163-18-P